Nicolsamide piritsi
Niclosamide ndi pakamwa bioavailable chlorinated salicylanilide, ndi anthelmintic ndi angathe antineoplastic ntchito.Pakamwa, niclosamide imapangitsa kuwonongeka kwa mtundu wa androgen receptor (AR) V7 (AR-V7) kudzera munjira ya proteasome-mediated.Izi zimachepetsa kufotokozera kwa mtundu wa AR, zimalepheretsa AR-V7-mediated transcriptal activation, ndi kuchepetsa kulembedwa kwa AR-V7 kwa prostate-specific antigen (PSA) gene proprover.Niclosamide imalepheretsanso AR-V7-mediated STAT3 phosphorylation ndi kuyambitsa.Izi zimalepheretsa kusaina kwapakati pa AR/STAT3 ndikuletsa kuwonekera kwa chibadwa cha STAT3.Zonsezi, izi zitha kulepheretsa kukula kwa ma cell a khansa a AR-V7-overexpressing.Mtundu wa AR-V7, womwe umasungidwa ndi kuphatikizika kolumikizana kwa AR exons 1/2/3/CE3, umayendetsedwa ndi mitundu ingapo yama cell a khansa, ndipo umalumikizidwa ndi kukula kwa khansa komanso kukana mankhwala omwe amatsata AR.
Zolemba:
Aliyense bolus cotnains 1250 mg niclosamide
Chizindikiro:
Kwa zinyama zomwe zili ndi paramphistomes, cestodiasis, monga ng'ombe ndi nkhosa za moniezia, avitellina centripunctata, ndi zina zotero.
Mlingo ndi Kagwiritsidwe:
Pakamwa pa 1kg kulemera kwa thupi.
Ng'ombe: 40-60 mg
Nkhosa: 60-70mg
Nthawi yochotsera:
Nkhosa: masiku 28.
Ng'ombe: masiku 28.
Kukula kwa phukusi: mapiritsi 5 pa chithuza, matuza 10 pabokosi lililonse
